Uburebure bwa gene ihindurwa nubuhanga gakondo ntabwo buri munsi ya 5kb, kandi igihe kinini igice cyahinduwe kigabanya intsinzi.Byongeye kandi, kugirango wubake icyerekezo kirekire cyo gukomanga / gukubita imbeba ukoresheje tekinoroji gakondo, imbeba za chimeric zigomba kororoka no kugenzurwa ibisekuruza 2-3 kugirango zibone imbeba zigenewe, kandi inzira yose itwara ibirenga 10- Amezi 12.
Ibyiza byo guhindura ibice birebire bya gene biri mubushobozi bwayo bwo gutsinda imbogamizi zuburyo bwa gakondo bwo guhindura gen.