Ingirabuzimafatizo bivugwa ko idahuje igitsina kuri gene runaka mugihe alleles imwe ya gene iba ihari kuri chromosomes zombi.
Imiterere yimbeba yabantu ifite uburyo butandukanye mubushakashatsi bwa sida, kanseri, indwara zandura, n'indwara zamaraso.
Knock-in (KI) ni tekinike ikoresha homologous recombination ya genes kugirango yimure gene ikora idasanzwe mumikorere ya homologique muri selile na genome, kandi ibone imvugo neza muri selile nyuma yo kongera kwiyubaka.
Ikoreshwa rya Knock-out (CKO) ni tekinoroji yihariye ya gene knockout yagezweho na sisitemu yo kwisubiramo.
MugusabaTurboMice ™tekinoroji, turashobora kwerekana mu buryo butaziguye ingirangingo fatizo nyuma yo guhindura gene muminsi 3-5, hanyuma tukubaka selile ya tetraploid, hanyuma tukabona imbeba za homosexous mult-locus zahinduwe nimbeba mumezi 3-5 nyuma yo gusambana nimbeba za nyina, zishobora kuzigama umwaka 1 kubakiriya bacu.
TurboMice ™tekinoroji ituma gene ihindura neza ibice birebire birenga 20kb, bityo bikorohereza umusaruro wihuse wubwoko bugoye nko kuba umuntu, gukomanga kwa knockout (CKO), hamwe nibice binini bikomanga (KI).