Ibicuruzwa birambuye

Ibicuruzwa

Isesengura ryimikorere ya farumasi

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Isesengura ryimiti ya farumasi bivuga gusuzuma no gusuzuma imikorere yibiyobyabwenge mugushikira ibyo bagenewe kuvura.Nintambwe yingenzi mugikorwa cyo guteza imbere ibiyobyabwenge kandi isobanura inyungu zishobora kugarukira hamwe n’imiti.

Binyuze mu isesengura ry’imiti ya farumasi, abashakashatsi bagamije kumenya uburyo imiti ikorana na reseptor yayo cyangwa sisitemu y’ibinyabuzima, biganisha ku kwifuza kwifata.

MingCeler irashobora gutanga ubwoko butandukanye bwimbeba nkimiterere yabantu hamwe na mutation ya gene ukurikije ibyo abakiriya bakeneye, cyane cyane imiterere yindwara zahinduwe na gene zishobora kwigana neza inzira yiterambere ryindwara zabantu, zishobora gukoreshwa mugusuzuma no gusesengura imikorere yibiyobyabwenge kandi kuzamura igipimo cyiterambere ryiterambere ryibiyobyabwenge.

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Kwipimisha amaraso ya biohimiki

-Mu vitro gukomanga cyangwa gukabya gukabije kwa gen zigenewe mumirongo ngirabuzimafatizo

-Mu vivo gukomanga cyangwa gukabya gukabije genes zigenewe muburyo bwimbeba

-Mu vivo imikorere ikora harimo gukura kw'ibibyimba, metastasis, nibindi ·

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Imyitwarire yinyamaswa

· Kwiga no kwibuka ubushobozi bwo gupima :

Amazi ya Morris maze (kwibuka kwigira ahantu, kwibuka gukora, kwibuka ububiko, kwiga bidahinduka, kwibuka hippocampal);Barnes maze (kwigira ahantu hamwe no kwibuka);

Ubwoba buteganijwe :

Kwibuka kumarangamutima, hippocampal-biterwa na Associative isobanura ubwoba, ubwoba-butari bushingiye kuri hippocampal bwitondewe ubwoba, kwibuka igihe kirekire, kwibuka igihe gito, kwibuka biterwa na amygdala, hamwe no gutinya ubwoba.

Ikizamini cyimyitwarire yamaganya :

Kuzamura Umusaraba Maze, Ikizamini cyubwoba buteganijwe, Ikizamini cyimyitwarire yo mu murima, Igisubizo gitangaje, nimyitwarire yimibereho.

Ibizamini by'imyitwarire yo kwiheba :

Ubushakashatsi bushya bwibidukikije biterwa na hypophagia, kugerageza kumanika umurizo, kugerageza koga ku gahato, ikizamini cyimyitwarire idahari, ikizamini cyimyitwarire yimibereho, no kubona ubufasha.

Ibizamini bijyanye n'imyitwarire y'ububabare :

Gupima ububabare ukoresheje isahani ishyushye, gupima ububabare ukizunguza umurizo (ubushyuhe bwa infragre hamwe nigitutu cyatewe)

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Reba

[1] Othman MZ, Hassan Z, Che Afite AT.Morris water maze: igikoresho kinini kandi gifatika mugusuzuma imyigire hamwe nibuka.Kwagura Anim.2022 Kanama 5; 71 (3): 264-280.doi: 10.1538 / expanim.21-0120.Epub 2022 Werurwe 18. PMID: 35314563;PMCID: PMC9388345.


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